Two sample MR report
HLA-A_Alveolar Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 24 | -0.0816117 | 0.1480366 | 0.5869884 |
| Weighted median | 24 | -0.0538776 | 0.0184646 | 0.0035242 |
| Inverse variance weighted | 24 | -0.0668014 | 0.0137198 | 0.0000011 |
| Simple mode | 24 | -0.0456139 | 0.0349627 | 0.2049185 |
| Weighted mode | 24 | -0.0461906 | 0.0352399 | 0.2028812 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 9.050808 | 22 | 0.9930624 |
| Inverse variance weighted | 9.060904 | 23 | 0.9957479 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0072411 | 0.072067 | 0.9208759 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0003866 | 0 | TRUE | 0.062759 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
